The discovery of this new way to regulate genes raises the exciting and eerie prospect that the activity of neurons (thought?) can transmit a message across generations. If this sounds like science fiction, it is because this is cutting-edge science that transforms our understanding of what animals can do. Finding the neurons that are best at transmitting RNA messages across generations – the transgenerational brain – is what we hope to accomplish with your help. With a generation time of just 3 days, a brain of just 302 neurons, and a sequenced genome that is easily edited, C. elegans is the organism of choice to define the first transgenerational brain.